Diabetes and Aging: From Treatment Goals to Pharmacologic Therapy
نویسندگان
چکیده
منابع مشابه
Pharmacologic therapy for type 2 diabetes mellitus.
Type 2 diabetes mellitus is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. An elevated rate of basal hepatic glucose production in the presence of hyperinsulinemia is the primary cause of fasting hyperglycemia; after a meal, impaired suppression of hepatic glucose production by insulin and decreased insulin-mediated glucose uptake by muscle ...
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Diabetes in older adults is a growing public health burden. The unprecedented aging of the world’s population is a major contributor to the diabetes epidemic, and older adults represent one of the fastest growing segments of the diabetes population. Of impending concern is that these numbers are projected to grow dramatically over the next few decades (1,2). Almost one-third of U.S. adults over...
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s of the 62nd ADA Scientific Sessions, Diabetes 51 [Suppl. 2], 2002). In the former group, insulin sensitivity, acute insulin responses to IV glucose, or glucose levels after OGTT did not change significantly 8 months after the end of the trial, while the latter group showed 26 and 39% falls in insulin sensitivity and insulin response and a 10% increase in glucose levels during the OGTT. Twenty...
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T ype 2 diabetes is the most common form of diabetes in humans and results from a combination of genetic and acquired factors that impair -cell function and tissue insulin sensitivity (1,2). However, there is growing evidence that -cell dysfunction is crucial for the development and progression of this form of diabetes (3,4). Reduced -cell functional mass in diabetes, and other categories of gl...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2019
ISSN: 1664-2392
DOI: 10.3389/fendo.2019.00045